DOK1 polyclonal antibody
产品名称： DOK1 polyclonal antibody
英文名称： DOK1 polyclonal antibody
产品编号： PAB5500
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DOK1.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding Y362 of human DOK1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The pre-B cell receptor signaling for apoptosis is negatively regulated by Fc gamma RIIB.
Kato I, Takai T, Kudo A.J Immunol. 2002 Jan 15;168(2):629-34.
- 2.
- Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.
Songyang Z, Yamanashi Y, Liu D, Baltimore D.J Biol Chem. 2001 Jan 26;276(4):2459-65. Epub 2000 Oct 19.
- 3.
- Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling.
Nemorin JG, Duplay P.J Biol Chem. 2000 May 12;275(19):14590-7.
- Entrez GeneID:
- 1796
- Gene Name:
- DOK1
- Gene Alias:
- MGC117395,MGC138860,P62DOK
- Gene Description:
- docking protein 1, 62kDa (downstream of tyrosine kinase 1)
- Omim ID:
- 602919
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. [provided by RefSeq
- Other Designations:
- Downstream of tyrosine kinase 1,docking protein 1,docking protein 1 (downstream of tyrosine kinase 1),docking protein 1, 62kD (downstream of tyrosine kinase 1)
- Related Disease