SMAD2 monoclonal antibody (M09), clone 3B4
产品名称： SMAD2 monoclonal antibody (M09), clone 3B4
英文名称： SMAD2 monoclonal antibody (M09), clone 3B4
产品编号： H00004087-M09
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a full length recombinant SMAD2.
- Immunogen:
- SMAD2 (NP_005892, 16 a.a. ~ 119 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- LGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSH
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2b Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.44 KDa) .
- MSDS:
Download
- Applications
- Western Blot (Cell lysate)
- SMAD2 monoclonal antibody (M09), clone 3B4 Western Blot analysis of SMAD2 expression in Hela NE ( Cat # L013V3 ).
- Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Entrez GeneID:
- 4087
- GeneBank Accession#:
- NM_005901
- Protein Accession#:
- NP_005892
- Gene Name:
- SMAD2
- Gene Alias:
- JV18,JV18-1,MADH2,MADR2,MGC22139,MGC34440,hMAD-2,hSMAD2
- Gene Description:
- SMAD family member 2
- Omim ID:
- 601366
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
- Other Designations:
- MAD, mothers against decapentaplegic homolog 2,Mad protein homolog,Mad, mothers against decapentaplegic homolog 2,Mad-related protein 2,SMAD, mothers against DPP homolog 2,Sma- and Mad-related protein 2,mother against DPP homolog 2
- Related Disease
- Adenocarcinoma
- Cleft Lip
- Cleft Palate
- Colitis, Ulcerative
- Colorectal Neoplasms
- Crohn's disease
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Hypertension, Pulmonary
- Inflammatory Bowel Diseases
- Liver Cirrhosis
- Obesity
- Osteoporosis
- Ovarian Failure, Premature
- Pancreatic cancer
- Pancreatic Neoplasms
- Polycystic Ovary Syndrome
- Puberty, Delayed
- Puberty, Precocious