HK1 Pre-design Chimera RNAi-RNAi技术-试剂-生物在线

产品名称： HK1 Pre-design Chimera RNAi

英文名称： HK1 Pre-design Chimera RNAi

产品编号： H00003098-R06

产品价格： 0

产品产地：台湾

品牌商标： Abnova

更新时间： null

使用范围： null

亚诺法生技股份有限公司（Abnova)

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Product Description:
Homo sapiens hexokinase 1 (HK1), nuclear gene encoding mitochondrial protein, transcript variant 4, mRNA.

Storage Instruction:
Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.

Note:
Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence.

1.
dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.

3.
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.

4.
siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.

Gene Summary:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq